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Protein RAB18 PDB 1x3s.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RAB18, RAB18LI1, WARBM3, member RAS oncogene family
External IDs MGI: 102790 HomoloGene: 40765 GeneCards: RAB18
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 27.5 – 27.54 Mb Chr 18: 6.77 – 6.79 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Ras-related protein Rab-18 is a protein that in humans is encoded by the RAB18 gene.[3][4]

Rab18 is a ubiquitously expressed protein with particularly high expression in the brain.[5] Rab18 was first characterised as an endosomal protein in epithelial cells of mouse kidney and intestines.[5] Subsequent studies revealed that Rab18 has a wide intracellular distribution; localising to the Golgi complex, endoplasmic reticulum, lipid droplets, and cytosol of various cell types.[6][7][8] In the brain, Rab18 has been isolated in association with synaptic vesicles[9][10] and has been observed to localise to secretory granules in neuroendocrine cells.[11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Schafer U, Seibold S, Schneider A, Neugebauer E (Feb 2000). "Isolation and characterisation of the human rab18 gene after stimulation of endothelial cells with histamine". FEBS Lett. 466 (1): 148–54. doi:10.1016/S0014-5793(99)01778-0. PMID 10648831. 
  4. ^ "Entrez Gene: RAB18 RAB18, member RAS oncogene family". 
  5. ^ a b Lütcke A, Parton RG, Murphy C, Olkkonen VM, Dupree P, Valencia A, Simons K, Zerial M (December 1994). "Cloning and subcellular localization of novel rab proteins reveals polarized and cell type-specific expression". J. Cell. Sci. 107 (12): 3437–48. PMID 7706395. 
  6. ^ Dejgaard SY, Murshid A, Erman A, Kizilay O, Verbich D, Lodge R, Dejgaard K, Ly-Hartig TB, Pepperkok R, Simpson JC, Presley JF (August 2008). "Rab18 and Rab43 have key roles in ER-Golgi trafficking". J. Cell. Sci. 121 (Pt 16): 2768–81. doi:10.1242/jcs.021808. PMID 18664496. 
  7. ^ Martin S, Driessen K, Nixon SJ, Zerial M, Parton RG (December 2005). "Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism". J. Biol. Chem. 280 (51): 42325–35. doi:10.1074/jbc.M506651200. PMID 16207721. 
  8. ^ Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T (June 2005). "Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane". J. Cell. Sci. 118 (Pt 12): 2601–11. doi:10.1242/jcs.02401. PMID 15914536. 
  9. ^ Burré J, Beckhaus T, Corvey C, Karas M, Zimmermann H, Volknandt W (September 2006). "Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis". Electrophoresis. 27 (17): 3488–96. doi:10.1002/elps.200500864. PMID 16944461. 
  10. ^ Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F, Jahn R (November 2006). "Molecular anatomy of a trafficking organelle". Cell. 127 (4): 831–46. doi:10.1016/j.cell.2006.10.030. PMID 17110340. 
  11. ^ Vazquez-Martinez R, Cruz-Garcia D, Duran-Prado M, Peinado JR, Castaño JP, Malagon MM (July 2007). "Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules". Traffic. 8 (7): 867–82. doi:10.1111/j.1600-0854.2007.00570.x. PMID 17488286. 

Further reading[edit]