RAB7B

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RAB7B
Identifiers
Aliases RAB7B, RAB7, member RAS oncogene family
External IDs MGI: 2442295 HomoloGene: 64833 GeneCards: RAB7B
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001164522
NM_001304839
NM_177403

NM_145509
NM_001311096

RefSeq (protein)

NP_001157994
NP_001291768
NP_796377

NP_001298025.1
NP_663484.1
NP_001298025
NP_663484

Location (UCSC) Chr 1: 205.98 – 206 Mb Chr 1: 131.69 – 131.72 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ras-related protein Rab-7b is a protein that in humans is encoded by the RAB7B gene.[3]

Function[edit]

Rab7 is a small GTPase that plays a role in the transport and degradation of proteins in endosomes and lysosomes in mammalian cells. Rab7b, is localized to lysosome-associated compartments and is selectively expressed in monocytic cells.[4] By promoting the degradation of toll-like receptor 4, RAB7B can negatively regulate the inflammatory activation of macrophages.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yang M, Chen T, Han C, Li N, Wan T, Cao X (June 2004). "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells". Biochem. Biophys. Res. Commun. 318 (3): 792–9. doi:10.1016/j.bbrc.2004.04.115. PMID 15144907. 
  4. ^ a b Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X (August 2007). "Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4". Blood. 110 (3): 962–71. doi:10.1182/blood-2007-01-066027. PMID 17395780. 

Further reading[edit]