RABEP1

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RABEP1
Protein RABEP1 PDB 1tu3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RABEP1, RAB5EP, RABPT5, rabaptin, RAB GTPase binding effector protein 1
External IDs MGI: 1860236 HomoloGene: 3451 GeneCards: RABEP1
RNA expression pattern
PBB GE RABEP1 203223 at fs.png

PBB GE RABEP1 214552 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001083585
NM_001291581
NM_001291582
NM_004703

NM_001291141
NM_001291142
NM_001291143
NM_019400

RefSeq (protein)

NP_001077054
NP_001278510
NP_001278511
NP_004694

Location (UCSC) Chr 17: 5.28 – 5.39 Mb Chr 11: 70.84 – 70.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene.[3][4] It belongs to rabaptin protein family.

Interactions[edit]

RABEP1 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Stenmark H, Vitale G, Ullrich O, Zerial M (Nov 1995). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell. 83 (3): 423–32. doi:10.1016/0092-8674(95)90120-5. PMID 8521472. 
  4. ^ "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1". 
  5. ^ a b c Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067Freely accessible. PMID 12505986. 
  6. ^ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology. 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. 
  7. ^ a b Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540Freely accessible. PMID 9524117. 
  8. ^ Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry. 272 (10): 6097–100. doi:10.1074/jbc.272.10.6097. PMID 9045618. 
  9. ^ Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters. 508 (2): 201–9. doi:10.1016/s0014-5793(01)02993-3. PMID 11718716. 

Further reading[edit]