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Rabaptin, RAB GTPase binding effector protein 1
Protein RABEP1 PDB 1tu3.png
PDB rendering based on 1tu3.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603616 MGI1860236 HomoloGene3451 GeneCards: RABEP1 Gene
RNA expression pattern
PBB GE RABEP1 214552 s at tn.png
PBB GE RABEP1 203223 at tn.png
More reference expression data
Species Human Mouse
Entrez 9135 54189
Ensembl ENSG00000029725 ENSMUSG00000020817
UniProt Q15276 O35551
RefSeq (mRNA) NM_001083585 NM_001291141
RefSeq (protein) NP_001077054 NP_001278070
Location (UCSC) Chr 17:
5.28 – 5.39 Mb
Chr 11:
70.84 – 70.94 Mb
PubMed search [1] [2]

Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene.[1][2] It belongs to rabaptin protein family.


RABEP1 has been shown to interact with:


  1. ^ a b Stenmark H, Vitale G, Ullrich O, Zerial M (Nov 1995). "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion". Cell 83 (3): 423–32. doi:10.1016/0092-8674(95)90120-5. PMID 8521472. 
  2. ^ "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1". 
  3. ^ a b c Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Jan 2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". The EMBO Journal 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986. 
  4. ^ Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S (Jul 2002). "Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain". Nature Structural Biology 9 (7): 527–31. doi:10.1038/nsb808. PMID 12042876. 
  5. ^ a b Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M (Apr 1998). "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal 17 (7): 1941–51. doi:10.1093/emboj/17.7.1941. PMC 1170540. PMID 9524117. 
  6. ^ Xiao GH, Shoarinejad F, Jin F, Golemis EA, Yeung RS (Mar 1997). "The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis". The Journal of Biological Chemistry 272 (10): 6097–100. PMID 9045618. 
  7. ^ Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T (Nov 2001). "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER". FEBS Letters 508 (2): 201–9. PMID 11718716. 

Further reading[edit]