RABGEF1

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RABGEF1
Protein RABGEF1 PDB 1txu.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRABGEF1, RABEX5, RAP1, rabex-5, RAB guanine nucleotide exchange factor 1
External IDsMGI: 1929459 HomoloGene: 8720 GeneCards: RABGEF1
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for RABGEF1
Genomic location for RABGEF1
Band7q11.21Start66,682,164 bp[1]
End66,811,464 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001287060
NM_001287061
NM_001287062
NM_014504

NM_001199059
NM_019983
NM_001359233

RefSeq (protein)

NP_001185988
NP_064367
NP_001346162

Location (UCSC)Chr 7: 66.68 – 66.81 MbChr 5: 130.17 – 130.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.[5][6][7]

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5(RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM].[7]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154710 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025340 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Dec 2002). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  6. ^ Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O (Dec 2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37–43. doi:10.1016/S0304-3835(00)00553-X. PMID 11098082.
  7. ^ a b "Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1".

Further reading[edit]