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Protein RABIF PDB 1fwq.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RABIF, MSS4, RASGFR3, RASGRF3, RAB interacting factor
External IDs MGI: 2138605 HomoloGene: 37702 GeneCards: RABIF
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RABIF
Genomic location for RABIF
Band 1q32.1 Start 202,878,957 bp[1]
End 202,889,135 bp[1]
RNA expression pattern
PBB GE RABIF 204477 at fs.png

PBB GE RABIF 204478 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 202.88 – 202.89 Mb Chr 1: 134.49 – 134.51 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.[5][6][7]


The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183155 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042229 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM (Mar 1998). "Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer". Genomics. 46 (3): 389–96. doi:10.1006/geno.1997.5049. PMID 9441742.  Check date values in: |year= / |date= mismatch (help)
  6. ^ Yu H, Schreiber SL (Aug 1995). "Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4". Biochemistry. 34 (28): 9103–10. doi:10.1021/bi00028a020. PMID 7619808. 
  7. ^ a b "Entrez Gene: RABIF RAB interacting factor". 

Further reading[edit]

  • Yu H, Schreiber SL (1995). "Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface". Nature. 376 (6543): 788–91. doi:10.1038/376788a0. PMID 7651540. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Burton JL, Slepnev V, De Camilli PV (1997). "An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4". J. Biol. Chem. 272 (6): 3663–8. doi:10.1074/jbc.272.6.3663. PMID 9013620. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M (1999). "Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains". FEBS Lett. 445 (2-3): 351–5. doi:10.1016/S0014-5793(99)00151-9. PMID 10094488. 
  • Strick DJ, Francescutti DM, Zhao Y, Elferink LA (2002). "Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis". J. Biol. Chem. 277 (36): 32722–9. doi:10.1074/jbc.M205101200. PMID 12105226. 
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.