RACGAP1

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RACGAP1
Protein RACGAP1 PDB 2ovj.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RACGAP1, CYK4, HsCYK-4, ID-GAP, MgcRacGAP, Rac GTPase activating protein 1
External IDs MGI: 1349423 HomoloGene: 8077 GeneCards: RACGAP1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253808
NM_001253809
NM_012025

RefSeq (protein)
Location (UCSC) Chr 12: 49.98 – 50.03 Mb Chr 15: 99.62 – 99.65 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene.[3]

Function[edit]

Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM][4]

Interactions[edit]

RACGAP1 has been shown to interact with Rnd2[5] and SLC26A8.[6]

During cytokinesis, RACGAP1 has been shown to interact with KIF23 to form the centralspindlin complex.[7] This complex is essential for the formation of the central spindle. RACGAP1 also interacts with PRC1 to stabilize and maintain the central spindle as anaphase proceeds.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Touré A, Dorseuil O, Morin L, Timmons P, Jégou B, Reibel L, Gacon G (March 1998). "MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells". The Journal of Biological Chemistry. 273 (11): 6019–23. doi:10.1074/jbc.273.11.6019. PMID 9497316. 
  4. ^ "Entrez Gene: RACGAP1 Rac GTPase activating protein 1". 
  5. ^ Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, Chardin P, Gacon G (May 2003). "Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells". The Biochemical Journal. 372 (Pt 1): 105–12. doi:10.1042/BJ20021652. PMC 1223378Freely accessible. PMID 12590651. 
  6. ^ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (June 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". The Journal of Biological Chemistry. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976. 
  7. ^ Glotzer M (February 2013). "Cytokinesis: centralspindlin moonlights as a membrane anchor". Current Biology. 23 (4): R145–7. doi:10.1016/j.cub.2013.01.006. PMID 23428321. 
  8. ^ Lee KY, Esmaeili B, Zealley B, Mishima M (2015). "Direct interaction between centralspindlin and PRC1 reinforces mechanical resilience of the central spindle". Nature Communications. 6: 7290. doi:10.1038/ncomms8290. PMC 4557309Freely accessible. PMID 26088160. 

Further reading[edit]