RAD21

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RAD21
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RAD21, CDLS4, HR21, HMCD1, NXP1, SCC1, hHR21, RAD21 cohesin complex component
External IDs MGI: 108016 HomoloGene: 38161 GeneCards: RAD21
RNA expression pattern
PBB GE RAD21 200608 s at fs.png

PBB GE RAD21 200607 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006265

NM_009009

RefSeq (protein)

NP_006256

NP_033035.3
NP_033035

Location (UCSC) Chr 8: 116.85 – 116.87 Mb Chr 15: 51.96 – 51.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene.[3][4]

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.[4]

Interactions[edit]

RAD21 has been shown to interact with SMARCA5.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McKay MJ, Troelstra C, van der Spek P, Kanaar R, Smit B, Hagemeijer A, Bootsma D, Hoeijmakers JH (Jan 1997). "Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse". Genomics. 36 (2): 305–15. doi:10.1006/geno.1996.0466. PMID 8812457. 
  4. ^ a b "Entrez Gene: RAD21 RAD21 homolog (S. pombe)". 
  5. ^ Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature. England. 418 (6901): 994–8. doi:10.1038/nature01024. ISSN 0028-0836. PMID 12198550. 

Further reading[edit]

External links[edit]