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Available structures
PDBOrtholog search: PDBe RCSB
AliasesRAD51D, BROVCA4, R51H3, RAD51L3, TRAD, RAD51 paralog D
External IDsOMIM: 602954 MGI: 1261809 HomoloGene: 2156 GeneCards: RAD51D
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RAD51D
Genomic location for RAD51D
Band17q12Start35,092,208 bp[1]
End35,121,522 bp[1]
RNA expression pattern
PBB GE RAD51L3 209965 s at fs.png

PBB GE RAD51L3 37793 r at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC)Chr 17: 35.09 – 35.12 MbChr 11: 82.88 – 82.89 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.[5][6]


The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.[6]


RAD51L3 has been shown to interact with:


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185379 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018841 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pittman DL, Weinberg LR, Schimenti JC (June 1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene". Genomics. 49 (1): 103–11. doi:10.1006/geno.1998.5226. PMID 9570954.
  6. ^ a b "Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae)".
  7. ^ a b Braybrooke JP, Li JL, Wu L, Caple F, Benson FE, Hickson ID (November 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. 278 (48): 48357–66. doi:10.1074/jbc.M308838200. hdl:10026.1/10297. PMID 12975363.
  8. ^ a b Liu N, Schild D, Thelen MP, Thompson LH (February 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113.
  9. ^ Miller KA, Yoshikawa DM, McConnell IR, Clark R, Schild D, Albala JS (March 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
  10. ^ Schild D, Lio YC, Collins DW, Tsomondo T, Chen DJ (June 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. 275 (22): 16443–9. doi:10.1074/jbc.M001473200. PMID 10749867.
  11. ^ Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG (June 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. 13 (12): 1241–8. doi:10.1093/hmg/ddh135. PMID 15115758.

Further reading[edit]