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RAD52 homolog, DNA repair protein
Protein RAD52 PDB 1h2i.png
PDB rendering based on 1h2i.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol RAD52
External IDs OMIM600392 HomoloGene31118 GeneCards: RAD52 Gene
RNA expression pattern
PBB GE RAD52 205647 at tn.png
PBB GE RAD52 210630 s at tn.png
PBB GE RAD52 211904 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5893 19365
Ensembl ENSG00000002016 ENSMUSG00000030166
UniProt P43351 P43352
RefSeq (mRNA) NM_001297419 NM_001166381
RefSeq (protein) NP_001284348 NP_001159853
Location (UCSC) Chr 12:
0.91 – 0.99 Mb
Chr 6:
119.9 – 119.92 Mb
PubMed search [1] [2]

RAD52 homolog (S. cerevisiae), also known as RAD52, is a protein which in humans is encoded by the RAD52 gene.[1][2]


The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51-related DNA recombination and repair.[2]


RAD52 has been shown to interact with RAD51.[3] The Rad52 will ease the loading of Rad51 on ssDNA by interfering with the RPA protein.


  1. ^ Shen Z, Denison K, Lobb R, Gatewood JM, Chen DJ (January 1995). "The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues". Genomics 25 (1): 199–206. doi:10.1016/0888-7543(95)80126-7. PMID 7774919. 
  2. ^ a b "Entrez Gene: RAD52 RAD52 homolog (S. cerevisiae)". 
  3. ^ Chen, G; Yuan S S, Liu W, Xu Y, Trujillo K, Song B, Cong F, Goff S P, Wu Y, Arlinghaus R, Baltimore D, Gasser P J, Park M S, Sung P, Lee E Y (Apr 1999). "Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl". J. Biol. Chem. (UNITED STATES) 274 (18): 12748–52. doi:10.1074/jbc.274.18.12748. ISSN 0021-9258. PMID 10212258. 

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