RAE1

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RAE1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RAE1, MIG14, MRNP41, Mnrp41, dJ481F12.3, dJ800J21.1, ribonucleic acid export 1
External IDs MGI: 1913929 HomoloGene: 2676 GeneCards: RAE1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001015885
NM_003610

NM_175112

RefSeq (protein)

NP_001015885
NP_003601

NP_780321.1
NP_780321

Location (UCSC) Chr 20: 57.35 – 57.38 Mb Chr 2: 173 – 173.02 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

mRNA export factor is a protein that in humans is encoded by the RAE1 gene.[3][4][5]

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[5]

Interactions[edit]

RAE1 has been shown to interact with NUP98.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bharathi A, Ghosh A, Whalen WA, Yoon JH, Pu R, Dasso M, Dhar R (Dec 1997). "The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA". Gene. 198 (1–2): 251–8. doi:10.1016/S0378-1119(97)00322-3. PMID 9370289. 
  4. ^ Kraemer D, Blobel G (Sep 1997). "mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm". Proc Natl Acad Sci U S A. 94 (17): 9119–24. doi:10.1073/pnas.94.17.9119. PMC 23064Freely accessible. PMID 9256445. 
  5. ^ a b "Entrez Gene: RAE1 RAE1 RNA export 1 homolog (S. pombe)". 
  6. ^ Pritchard, C E; Fornerod M; Kasper L H; van Deursen J M (Apr 1999). "RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains". J. Cell Biol. UNITED STATES. 145 (2): 237–54. doi:10.1083/jcb.145.2.237. ISSN 0021-9525. PMC 2133102Freely accessible. PMID 10209021. 

Further reading[edit]