RAMP1

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RAMP1
PDB 2yx8 EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RAMP1, entrez:10267, receptor activity modifying protein 1
External IDs OMIM: 605153 MGI: 1858418 HomoloGene: 4275 GeneCards: RAMP1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308353
NM_005855

NM_001168392
NM_016894
NM_178401

RefSeq (protein)

NP_001295282
NP_005846

NP_058590.1
NP_001161864
NP_058590
NP_848488

Location (UCSC) Chr 2: 237.86 – 237.91 Mb Chr 1: 91.18 – 91.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.[3][4]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.[3] The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY1 [5]

See also[edit]

Receptor activity-modifying protein

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: RAMP1". 
  4. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. doi:10.1038/30666. PMID 9620797. 
  5. ^ *"Calcitonin Receptors: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.