RAMP3

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RAMP3
Identifiers
Aliases RAMP3, entrez:10268, receptor activity modifying protein 3
External IDs OMIM: 605155 MGI: 1860292 HomoloGene: 4276 GeneCards: RAMP3
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for RAMP3
Genomic location for RAMP3
Band 7p13 Start 45,157,791 bp[1]
End 45,186,302 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005856

NM_019511

RefSeq (protein)

NP_005847

NP_062384

Location (UCSC) Chr 7: 45.16 – 45.19 Mb Chr 7: 6.66 – 6.68 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.[5][6]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122679 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041046 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: RAMP3". 
  6. ^ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–9. PMID 9620797. doi:10.1038/30666. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.