RAP1GDS1

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RAP1GDS1
Identifiers
AliasesRAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDsOMIM: 179502 MGI: 2385189 HomoloGene: 41422 GeneCards: RAP1GDS1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040690
NM_001286759
NM_145544
NM_001356388

RefSeq (protein)

NP_001035780
NP_001273688
NP_001343317
NP_663519

Location (UCSC)Chr 4: 98.26 – 98.44 MbChr 3: 138.63 – 138.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[5][6][7]


Interactions[edit]

RAP1GDS1 has been shown to interact with KIFAP3,[8] HRAS[9] and RHOA.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138698 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028149 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. S2CID 21189125.
  6. ^ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244.
  7. ^ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
  8. ^ Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189.
  9. ^ a b Vikis HG, Stewart Scott, Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. S2CID 6647800.

Further reading[edit]