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RAP1, GTP-GDP dissociation stimulator 1
Symbols RAP1GDS1 ; GDS1; SmgGDS
External IDs OMIM179502 MGI2385189 HomoloGene41422 GeneCards: RAP1GDS1 Gene
RNA expression pattern
PBB GE RAP1GDS1 209444 at tn.png
PBB GE RAP1GDS1 217457 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5910 229877
Ensembl ENSG00000138698 ENSMUSG00000028149
UniProt P52306 Q3TPS9
RefSeq (mRNA) NM_001100426 NM_001040690
RefSeq (protein) NP_001093896 NP_001035780
Location (UCSC) Chr 4:
98.26 – 98.44 Mb
Chr 3:
138.93 – 139.08 Mb
PubMed search [1] [2]

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[1][2][3]


RAP1GDS1 has been shown to interact with KIFAP3,[4] HRAS[5] and RHOA.[5]


  1. ^ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet 92 (6): 629–30. doi:10.1007/BF00420952. PMID 8262526. 
  2. ^ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem 283 (2): 963–76. doi:10.1074/jbc.M707526200. PMID 17951244. 
  3. ^ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1". 
  4. ^ Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. (UNITED STATES) 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. ISSN 0021-9258. PMID 8900189. 
  5. ^ a b Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene (England) 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN 0950-9232. PMID 11948427. 

Further reading[edit]

  • Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21.". Oncogene 7 (2): 289–93. PMID 1549351. 
  • Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase.". J. Biol. Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189. 
  • Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms.". Oncogene 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID 11948427. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.". J. Biol. Chem. 278 (25): 22412–7. doi:10.1074/jbc.M212036200. PMID 12690117. 
  • Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.". Blood 103 (7): 2661–7. doi:10.1182/blood-2003-06-2154. PMID 14615375. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.