RAR-related orphan receptor beta

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Protein RORB PDB 1k4w.png
Aliases RORB, NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1, RAR-related orphan receptor beta, RAR related orphan receptor B
External IDs MGI: 1343464 HomoloGene: 38250 GeneCards: 6096
Genetically Related Diseases
refractive error[1]
Targeted by Drug
all-trans-retinoic acid[2]
RNA expression pattern
PBB GE RORB 206443 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 9: 74.5 – 74.69 Mb Chr 19: 18.93 – 19.11 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.[5]


The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.[6]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[7]


RAR-related orphan receptor beta has been shown to interact with NME1.[8]

See also[edit]


  1. ^ "Diseases that are genetically associated with RORB view/edit references on wikidata". 
  2. ^ "Drugs that physically interact with Nuclear receptor ROR-beta view/edit references on wikidata". 
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749. 
  6. ^ "Entrez Gene: RORB RAR-related orphan receptor B". 
  7. ^ Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex. 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343free to read. PMID 21799210. 
  8. ^ Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107. 

Further reading[edit]

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