RAR-related orphan receptor beta

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RAR-related orphan receptor B
Protein RORB PDB 1k4w.png
PDB rendering based on 1k4w.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RORB ; NR1F2; ROR-BETA; RZR-BETA; RZRB; bA133M9.1
External IDs OMIM601972 MGI1343464 HomoloGene38250 IUPHAR: 599 GeneCards: RORB Gene
RNA expression pattern
PBB GE RORB 206443 at tn.png
More reference expression data
Species Human Mouse
Entrez 6096 225998
Ensembl ENSG00000198963 ENSMUSG00000036192
UniProt Q92753 Q8R1B8
RefSeq (mRNA) NM_006914 NM_001043354
RefSeq (protein) NP_008845 NP_001036819
Location (UCSC) Chr 9:
74.5 – 74.69 Mb
Chr 19:
18.93 – 19.11 Mb
PubMed search [1] [2]

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 (nuclear receptor subfamily 1, group F, member 2) is a nuclear receptor that in humans is encoded by the RORB gene.[1]


The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside-diphosphate kinase involved in organogenesis and differentiation.[2]

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.[3]


RAR-related orphan receptor beta has been shown to interact with NME1.[4]

See also[edit]


  1. ^ Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G (March 1994). "Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors". Genes Dev. 8 (5): 538–53. doi:10.1101/gad.8.5.538. PMID 7926749. 
  2. ^ "Entrez Gene: RORB RAR-related orphan receptor B". 
  3. ^ Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD (May 2012). "RORβ induces barrel-like neuronal clusters in the developing neocortex". Cereb. Cortex 22 (5): 996–1006. doi:10.1093/cercor/bhr182. PMC 3328343. PMID 21799210. 
  4. ^ Paravicini G, Steinmayr M, André E, Becker-André M (October 1996). "The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily". Biochem. Biophys. Res. Commun. 227 (1): 82–7. doi:10.1006/bbrc.1996.1471. PMID 8858107. 

Further reading[edit]

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