RASA4

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RASA4
Identifiers
Aliases RASA4, CAPRI, GAPL, RAS p21 protein activator 4
External IDs MGI: 1858600 HomoloGene: 5080 GeneCards: RASA4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001079877
NM_006989

NM_001039103
NM_133914

RefSeq (protein)

NP_001073346
NP_008920

NP_001034192.1
NP_598675.2
NP_001034192
NP_598675

Location (UCSC) Chr 7: 102.57 – 102.62 Mb Chr 5: 136.08 – 136.11 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[3][4]

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lockyer PJ, Kupzig S, Cullen PJ (Jul 2001). "CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway". Curr Biol. 11 (12): 981–6. doi:10.1016/S0960-9822(01)00261-5. PMID 11448776. 
  4. ^ a b "Entrez Gene: RASA4 RAS p21 protein activator 4". 

Further reading[edit]

External links[edit]