RASAL2

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RASAL2
Identifiers
Aliases RASAL2, NGAP, RAS protein activator like 2
External IDs MGI: 2443881 HomoloGene: 35217 GeneCards: RASAL2
Genetically Related Diseases
smallpox[1]
RNA expression pattern
PBB GE RASAL2 219026 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004841
NM_170692

NM_177644

RefSeq (protein)

NP_004832
NP_733793

n/a

Location (UCSC) Chr 1: 178.09 – 178.48 Mb Chr 1: 157.14 – 157.41 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.[4][5]

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[5]

References[edit]

  1. ^ "Diseases that are genetically associated with RASAL2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M (Jan 1999). "A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25". FEBS Lett. 441 (1): 127–31. doi:10.1016/S0014-5793(98)01530-0. PMID 9877179. 
  5. ^ a b "Entrez Gene: RASAL2 RAS protein activator like 2". 

Further reading[edit]