RASD2

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RASD2
Identifiers
Aliases RASD2, MGC:4834, Rhes, TEM2, RASD family member 2
External IDs MGI: 1922391 HomoloGene: 8628 GeneCards: RASD2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014310

NM_029182

RefSeq (protein)

NP_055125

NP_083458.1
NP_083458

Location (UCSC) Chr 22: 35.54 – 35.55 Mb Chr 8: 75.21 – 75.22 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.[3][4][5][6]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. doi:10.1126/science.289.5482.1197. PMID 10947988. 
  4. ^ Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res. 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249. 
  5. ^ Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584. 
  6. ^ a b "Entrez Gene: RASD2 RASD family, member 2". 

Further reading[edit]