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Aliases RASGRP3, GRP3, RAS guanyl releasing protein 3
External IDs MGI: 3028579 HomoloGene: 15019 GeneCards: RASGRP3
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for RASGRP3
Genomic location for RASGRP3
Band 2p22.3 Start 33,436,324 bp[1]
End 33,564,750 bp[1]
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 2: 33.44 – 33.56 Mb Chr 2: 75.44 – 75.53 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[5][6][7]


Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[7]


RASGRP3 has been shown to interact with PRKCD.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152689 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071042 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. 
  6. ^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". The Journal of Biological Chemistry. 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204. 
  7. ^ a b "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)". 
  8. ^ Brodie C, Steinhart R, Kazimirsky G, Rubinfeld H, Hyman T, Ayres JN, Hur GM, Toth A, Yang D, Garfield SH, Stone JC, Blumberg PM (Jul 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Molecular Pharmacology. 66 (1): 76–84. doi:10.1124/mol.66.1.76. PMID 15213298. 

Further reading[edit]