RASSF2

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
RASSF2
Identifiers
AliasesRASSF2, CENP-34, RASFADIN, Ras association domain family member 2
External IDsMGI: 2442060 HomoloGene: 22840 GeneCards: RASSF2
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for RASSF2
Genomic location for RASSF2
Band20p13Start4,780,023 bp[1]
End4,823,645 bp[1]
RNA expression pattern
PBB GE RASSF2 203185 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014737
NM_170774

NM_175445
NM_001362866

RefSeq (protein)

NP_055552
NP_739580

NP_780654
NP_001349795

Location (UCSC)Chr 20: 4.78 – 4.82 MbChr 2: 131.99 – 132.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[5][6][7]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[7]

Interactions[edit]

RASSF2 has been shown to interact with KRAS.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101265 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027339 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  6. ^ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169.
  7. ^ a b "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
  8. ^ Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644.

Further reading[edit]