RASSF2

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RASSF2
Identifiers
Aliases RASSF2, CENP-34, RASFADIN, Ras association domain family member 2
External IDs MGI: 2442060 HomoloGene: 22840 GeneCards: RASSF2
RNA expression pattern
PBB GE RASSF2 203185 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014737
NM_170774

NM_175445

RefSeq (protein)

NP_055552
NP_739580

NP_780654.1
NP_780654

Location (UCSC) Chr 20: 4.78 – 4.82 Mb Chr 2: 131.99 – 132.03 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.[3][4][5]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.[5]

Interactions[edit]

RASSF2 has been shown to interact with KRAS.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849. 
  4. ^ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. doi:10.1038/sj.onc.1208566. PMID 15806169. 
  5. ^ a b "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2". 
  6. ^ Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. doi:10.1074/jbc.M300554200. ISSN 0021-9258. PMID 12732644. 

Further reading[edit]