RB-3007

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
RB-3007
RB-3007.svg
Names
Preferred IUPAC name
Benzyl (9S,12S)-7-[(R)-amino(phenyl)methyl]-9-[([1,1′-biphenyl]-4-yl)methyl]-12-methyl-2,7,10-trioxo-6-oxa-3-thia-11-aza-7λ5-phosphatridecan-13-oate
Other names
RB3007, LS-15768
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C37H41N2O6PS/c1-27(37(42)44-25-30-12-6-3-7-13-30)39-36(41)34(24-29-18-20-32(21-19-29)31-14-8-4-9-15-31)26-46(43,45-22-23-47-28(2)40)35(38)33-16-10-5-11-17-33/h3-21,27,34-35H,22-26,38H2,1-2H3,(H,39,41)/t27-,34+,35+,46?/m0/s1
    Key: PYJMLILRVYLUHW-UNCDKACKSA-N
  • C[C@H](NC(=O)[C@H](CC1=CC=C(C=C1)C1=CC=CC=C1)CP(=O)(OCCSC(C)=O)[C@@H](N)C1=CC=CC=C1)C(=O)OCC1=CC=CC=C1
Properties
C37H41N2O6PS
Molar mass 672.78 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

RB-3007 is an orally active analogue of RB-101. It acts as an enkephalinase inhibitor, which is used in scientific research.[1][2]

See also[edit]

  • RB-101 - enkephalinase inhibitor that produces analgesia without respiratory depression
  • D/DL-Phenylalanine - D-phenylalanine blockage of enkephalin degradation may be responsible for the reputed analgesic effect of DL-Phenylalanine
  • Racecadotril - an antidiarrheal drug which acts as a peripheral enkephalinase inhibitor
  • Ecadotril - a neutral endopeptidase inhibitor

References[edit]

  1. ^ Thanawala, V.; Kadam, V.; Ghosh, R. (1 October 2008). "Enkephalinase Inhibitors: Potential Agents for the Management of Pain". Current Drug Targets. 9 (10): 887–894. doi:10.2174/138945008785909356. PMID 18855623.
  2. ^ Noble, Florence; Roques, Bernard P (17 January 2007). "Protection of endogenous enkephalin catabolism as natural approach to novel analgesic and antidepressant drugs". Expert Opinion on Therapeutic Targets. 11 (2): 145–159. doi:10.1517/14728222.11.2.145. PMID 17227231. S2CID 24437682.