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Aliases RB1CC1, ATG17, CC1, FIP200, PPP1R131, RB1 inducible coiled-coil 1
External IDs MGI: 1341850 HomoloGene: 7659 GeneCards: RB1CC1
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for RB1CC1
Genomic location for RB1CC1
Band 8q11.23 Start 52,622,456 bp[1]
End 52,745,843 bp[1]
RNA expression pattern
PBB GE RB1CC1 202034 x at fs.png

PBB GE RB1CC1 202033 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 52.62 – 52.75 Mb Chr 8: 6.21 – 6.28 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene.[5][6][7][8]


RB1CC1 has been shown to interact with PTK2B,[9] ASK1[10] and PTK2.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000023287 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025907 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Chano T, Ikegawa S, Kontani K, Okabe H, Baldini N, Saeki Y (Feb 2002). "Identification of RB1CC1, a novel human gene that can induce RB1 in various human cells". Oncogene. 21 (8): 1295–8. doi:10.1038/sj.onc.1205171. PMID 11850849. 
  6. ^ Maucuer A, Camonis JH, Sobel A (Apr 1995). "Stathmin interaction with a putative kinase and coiled-coil-forming protein domains". Proceedings of the National Academy of Sciences of the United States of America. 92 (8): 3100–4. doi:10.1073/pnas.92.8.3100. PMC 42112Freely accessible. PMID 7724523. 
  7. ^ Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells". The Journal of Cell Biology. 181 (3): 497–510. doi:10.1083/jcb.200712064. PMC 2364687Freely accessible. PMID 18443221. 
  8. ^ "Entrez Gene: RB1CC1 RB1-inducible coiled-coil 1". 
  9. ^ a b Ueda H, Abbi S, Zheng C, Guan JL (Apr 2000). "Suppression of Pyk2 kinase and cellular activities by FIP200". The Journal of Cell Biology. 149 (2): 423–30. doi:10.1083/jcb.149.2.423. PMC 2175150Freely accessible. PMID 10769033. 
  10. ^ Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL (Oct 2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways". The Journal of Cell Biology. 175 (1): 121–33. doi:10.1083/jcb.200604129. PMC 2064504Freely accessible. PMID 17015619. 

Further reading[edit]