RBBP5

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RBBP5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RBBP5, RBQ3, SWD1, retinoblastoma binding protein 5, RB binding protein 5, histone lysine methyltransferase complex subunit
External IDs MGI: 1918367 HomoloGene: 3709 GeneCards: RBBP5
RNA expression pattern
PBB GE RBBP5 205169 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193272
NM_001193273
NM_005057

NM_172517

RefSeq (protein)

NP_001180201
NP_001180202
NP_005048

NP_766105.2
NP_766105

Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.48 – 132.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.[3][4]

Function[edit]

The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.[4]

Interactions[edit]

RBBP5 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Saijo M, Sakai Y, Kishino T, Niikawa N, Matsuura Y, Morino K, Tamai K, Taya Y (Jun 1995). "Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping". Genomics. 27 (3): 511–9. doi:10.1006/geno.1995.1084. PMID 7558034. 
  4. ^ a b "Entrez Gene: RBBP5 retinoblastoma binding protein 5". 
  5. ^ a b c Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/mcb.23.1.140-149.2003. PMC 140670Freely accessible. PMID 12482968. 
  6. ^ Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (Jul 2004). "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression". Molecular and Cellular Biology. 24 (13): 5639–49. doi:10.1128/MCB.24.13.5639-5649.2004. PMC 480881Freely accessible. PMID 15199122. 

Further reading[edit]