This article needs additional citations for verification. (June 2016) (Learn how and when to remove this template message)
rBCG30 (recombinant Bacillus Calmette-Guérin 30) is a prospective vaccine against tuberculosis created by a team headed by Marcus A. Horwitz at UCLA. It is a live vaccine, consisting of BCG genetically modified to produce abundant amounts of a 30kDa antigen (Antigen 85B) that has been shown to produce a strong immune response in animals and humans. The vaccine completed a Phase I double-blind randomized controlled clinical trial that demonstrated that rBCG30 was safe and immunogenic; during nine months of follow-up, rBCG30, but not BCG, induced significantly increased Antigen 85B-specific immune responses in eight immunological assays (blood lymphocyte proliferation, antibody responses by ELISA, interferon-gamma producing CD4+ and CD8+ T cells ex vivo, central memory CD4+ and CD8+ T cells, interferon-gamma ELISPOT responses, and the capacity of T cells to activate macrophages to inhibit mycobacterial intracellular multiplication).
- Horwitz MA, Harth G, Dillon BJ, Maslesa-Galic' S (December 2000). "Recombinant bacillus calmette-guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13853–8. PMC . PMID 11095745. doi:10.1073/pnas.250480397.
- Horwitz MA, Harth G (April 2003). "A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis". Infect. Immun. 71 (4): 1672–9. PMC . PMID 12654780. doi:10.1128/iai.71.4.1672-1679.2003.
- Horwitz MA, Harth G, Dillon BJ, Maslesa-Galić S (January 2006). "Extraordinarily few organisms of a live recombinant BCG vaccine against tuberculosis induce maximal cell-mediated and protective immunity". Vaccine. 24 (4): 443–51. PMID 16125825. doi:10.1016/j.vaccine.2005.08.001.
- Horwitz MA, Harth G, Dillon BJ, Maslesa-Galić S (March 2006). "A novel live recombinant mycobacterial vaccine against bovine tuberculosis more potent than BCG". Vaccine. 24 (10): 1593–600. PMID 16257099. doi:10.1016/j.vaccine.2005.10.002.
- Hoft DF, Blazevic A, Abate G, et al. (November 2008). "A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers". J. Infect. Dis. 198 (10): 1491–501. PMC . PMID 18808333. doi:10.1086/592450.
|This vaccine article is a stub. You can help Wikipedia by expanding it.|