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Protein RBM9 PDB 2cq3.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRBFOX2, FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh, RNA binding protein, fox-1 homolog 2, RNA binding fox-1 homolog 2
External IDsMGI: 1933973 HomoloGene: 49375 GeneCards: RBFOX2
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for RBFOX2
Genomic location for RBFOX2
Band22q12.3Start35,738,736 bp[1]
End36,028,425 bp[1]
RNA expression pattern
PBB GE RBM9 212104 s at fs.png

PBB GE RBM9 213901 x at fs.png
More reference expression data
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 22: 35.74 – 36.03 MbChr 15: 77.08 – 77.31 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

RNA binding motif protein 9 (RBM9), also known as Rbfox2, is a protein which in humans is encoded by the RBM9 gene.[5]


Rbfox2 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative splicing in the nervous system and other cell types. Rbfox2 and the related protein Rbfox1 bind to conserved (U)GCAUG RNA motifs in the introns adjacent to many alternatively spliced exons and promotes inclusion or exclusion of the alternative exon in mature transcripts.[6][7] The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Rbfox2, as determined by CLIP-seq, binds near alternatively spliced exons and regulates the inclusion or exclusion of exons during alternative splicing by binding in introns either downstream (inclusion) or upstream (exon skipping) of exons. Its presence is important for stem cell survival and knockdowns of Rbfox2 activate markers for apoptosis.[8]

See also[edit]


  1. ^ a b c ENSG00000100320 GRCh38: Ensembl release 89: ENSG00000277564, ENSG00000100320 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033565 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: RBM9 RNA binding motif protein 9". 
  6. ^ Jin, Y. (2003-02-17). "A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG". The EMBO Journal. Wiley-Blackwell. 22 (4): 905–912. doi:10.1093/emboj/cdg089. ISSN 1460-2075. PMC 145449Freely accessible. 
  7. ^ Ponthier, Julie L.; Schluepen, Christina; Chen, Weiguo; Lersch, Robert A.; Gee, Sherry L.; Hou, Victor C.; Lo, Annie J.; Short, Sarah A.; Chasis, Joel A.; Winkelmann, John C.; Conboy, John G. (2006-03-14). "Fox-2 Splicing Factor Binds to a Conserved Intron Motif to Promote Inclusion of Protein 4.1R Alternative Exon 16". Journal of Biological Chemistry. American Society for Biochemistry & Molecular Biology (ASBMB). 281 (18): 12468–12474. doi:10.1074/jbc.m511556200. ISSN 0021-9258. 
  8. ^ Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH (February 2009). "An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells". Nature Structural & Molecular Biology. 16 (2): 130–137. doi:10.1038/nsmb.1545. PMC 2735254Freely accessible. PMID 19136955. 

Further reading[edit]