RBP1

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RBP1
Protein RBP1 PDB 1crb.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RBP1, CRABP-I, CRBP, CCRBPI, RBPC, retinol binding protein 1
External IDs MGI: 97876 HomoloGene: 2175 GeneCards: RBP1
RNA expression pattern
PBB GE RBP1 203423 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002899
NM_001130992
NM_001130993

NM_011254

RefSeq (protein)

NP_001124464
NP_001124465
NP_002890

NP_035384

Location (UCSC) Chr 3: 139.52 – 139.54 Mb Chr 9: 98.42 – 98.45 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.[3][4][5]

Function[edit]

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.[3]

Clinical significance[edit]

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: RBP1 retinol binding protein 1, cellular". 
  4. ^ Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ (September 1991). "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro". J. Biol. Chem. 266 (26): 17662–6. PMID 1654334. 
  5. ^ De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L (1998). "Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization". Cytogenet. Cell Genet. 82 (3-4): 226–7. PMID 9858824. doi:10.1159/000015107. 
  6. ^ Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B (June 2006). "Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications". Mod. Pathol. 19 (6): 797–803. PMID 16575402. doi:10.1038/modpathol.3800586. 

Further reading[edit]