RCOR1

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RCOR1
Protein RCOR1 PDB 2iw5.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RCOR1, COREST, RCOR, REST corepressor 1
External IDs MGI: 106340 HomoloGene: 32246 GeneCards: RCOR1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015156

NM_198023

RefSeq (protein)

NP_055971

NP_932140.1
NP_932140

Location (UCSC) Chr 14: 102.59 – 102.73 Mb Chr 12: 111.04 – 111.12 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.[3][4]

Function[edit]

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).[4]

Interactions[edit]

RCOR1 has been shown to interact with

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. doi:10.1073/pnas.96.17.9873. PMC 22303Freely accessible. PMID 10449787. 
  4. ^ a b "Entrez Gene: RCOR1 REST corepressor 1". 
  5. ^ a b c d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246Freely accessible. PMID 12032298. 
  6. ^ a b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278Freely accessible. PMID 11171972. 
  7. ^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272. 

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.