RCOR1

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RCOR1
Protein RCOR1 PDB 2iw5.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRCOR1, COREST, RCOR, REST corepressor 1
External IDsMGI: 106340 HomoloGene: 32246 GeneCards: RCOR1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RCOR1
Genomic location for RCOR1
Band14q32.31-q32.32Start102,592,649 bp[1]
End102,730,561 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015156

NM_198023

RefSeq (protein)

NP_055971

NP_932140

Location (UCSC)Chr 14: 102.59 – 102.73 MbChr 12: 111.04 – 111.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.[5][6]

Function[edit]

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).[6]

Interactions[edit]

RCOR1 has been shown to interact with

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089902 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037896 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G (September 1999). "CoREST: a functional corepressor required for regulation of neural-specific gene expression". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9873–8. doi:10.1073/pnas.96.17.9873. PMC 22303. PMID 10449787.
  6. ^ a b "Entrez Gene: RCOR1 REST corepressor 1".
  7. ^ a b c d Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R (May 2002). "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. doi:10.1073/pnas.112008599. PMC 124246. PMID 12032298.
  8. ^ a b You A, Tong JK, Grozinger CM, Schreiber SL (February 2001). "CoREST is an integral component of the CoREST- human histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1454–8. doi:10.1073/pnas.98.4.1454. PMC 29278. PMID 11171972.
  9. ^ Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T (September 2004). "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.

Further reading[edit]


This article incorporates text from the United States National Library of Medicine, which is in the public domain.