REG1B

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REG1B
Identifiers
Aliases REG1B, PSPS2, REGH, REGI-BETA, REGL, regenerating family member 1 beta
External IDs MGI: 97896 HomoloGene: 68517 GeneCards: 5968
RNA expression pattern
PBB GE REG1B 205886 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006507

NM_009043

RefSeq (protein)

NP_006498.1

NP_033069.1

Location (UCSC) Chr 2: 79.09 – 79.09 Mb Chr 6: 78.4 – 78.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Lithostathine-1-beta is a protein that in humans is encoded by the REG1B gene.[1][2]

Function[edit]

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandomly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication.[2]

References[edit]

  1. ^ Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H, Okamoto H (Mar 1994). "Isolation, structural determination and expression of a novel reg gene, human regI beta". Biochim Biophys Acta 1217 (2): 199–202. doi:10.1016/0167-4781(94)90035-3. PMID 8110835. 
  2. ^ a b "Entrez Gene: REG1B regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)". 

Further reading[edit]