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Regulatory factor X, 3 (influences HLA class II expression)
Symbols RFX3 ; bA32F11.1
External IDs OMIM601337 MGI106582 HomoloGene7917 GeneCards: RFX3 Gene
RNA expression pattern
PBB GE RFX3 207234 at tn.png
More reference expression data
Species Human Mouse
Entrez 5991 19726
Ensembl ENSG00000080298 ENSMUSG00000040929
UniProt P48380 P48381
RefSeq (mRNA) NM_001282116 NM_001166414
RefSeq (protein) NP_001269045 NP_001159886
Location (UCSC) Chr 9:
3.22 – 3.53 Mb
Chr 19:
27.76 – 28.01 Mb
PubMed search [1] [2]

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.[1][2]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.[2]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.