Transcription factor RFX3 is a protein that in humans is encoded by the RFX3gene.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.
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Nakayama A, Murakami H, Maeyama N et al. (2003). "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter.". J. Biol. Chem.278 (1): 233–40. doi:10.1074/jbc.M209574200. PMID12411430.
Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.". Arch. Dermatol. Res.295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID15024578.