RFX3

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
RFX3
Identifiers
AliasesRFX3, regulatory factor X3
External IDsMGI: 106582 HomoloGene: 7917 GeneCards: RFX3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for RFX3
Genomic location for RFX3
Band9p24.2Start3,218,297 bp[1]
End3,526,004 bp[1]
RNA expression pattern
PBB GE RFX3 207234 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282116
NM_001282117
NM_002919
NM_134428

NM_001166414
NM_011265
NM_001360357
NM_001360358

RefSeq (protein)

NP_001269045
NP_001269046
NP_002910
NP_602304

NP_001159886
NP_035395
NP_001347286
NP_001347287

Location (UCSC)Chr 9: 3.22 – 3.53 MbChr 19: 27.76 – 28.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.[5][6]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080298 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040929 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. PMC 358479. PMID 8289803.
  6. ^ a b "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.