The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes.
Takata, R.; Akamatsu, S.; Kubo, M.; Takahashi, A.; Hosono, N.; Kawaguchi, T.; Tsunoda, T.; Inazawa, J.; Kamatani, N.; Ogawa, O.; Fujioka, T.; Nakamura, Y.; Nakagawa, H. (2010). "Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population". Nature Genetics42 (9): 751–754. doi:10.1038/ng.635. PMID20676098.