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Regulator of G-protein signaling 10
Protein RGS10 PDB 2dlr.png
PDB rendering based on 2dlr.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol RGS10
External IDs OMIM602856 MGI1915115 HomoloGene37710 IUPHAR: 2818 GeneCards: RGS10 Gene
RNA expression pattern
PBB GE RGS10 204319 s at tn.png
PBB GE RGS10 204316 at tn.png
More reference expression data
Species Human Mouse
Entrez 6001 67865
Ensembl ENSG00000148908 ENSMUSG00000030844
UniProt O43665 Q9CQE5
RefSeq (mRNA) NM_001005339 NM_026418
RefSeq (protein) NP_001005339 NP_080694
Location (UCSC) Chr 10:
121.26 – 121.3 Mb
Chr 7:
128.37 – 128.42 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 10 is a protein that in humans is encoded by the RGS10 gene.[1][2]

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.[2]


RGS10 has been shown to interact with SAP18[3] and GNAI3.[1]


  1. ^ a b Hunt TW, Fields TA, Casey PJ, Peralta EG (Oct 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883. 
  2. ^ a b "Entrez Gene: RGS10 regulator of G-protein signalling 10". 
  3. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

Further reading[edit]