RGS11

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RGS11
Identifiers
Aliases RGS11, RS11, regulator of G-protein signaling 11
External IDs MGI: 1354739 HomoloGene: 77719 GeneCards: RGS11
RNA expression pattern
PBB GE RGS11 211872 s at fs.png

PBB GE RGS11 206107 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286485
NM_001286486
NM_003834
NM_183337

NM_001081069

RefSeq (protein)

NP_001273414
NP_001273415
NP_003825
NP_899180

NP_001074538

Location (UCSC) Chr 16: 0.27 – 0.28 Mb Chr 17: 26.2 – 26.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene.[3][4]

The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (Nov 1998). "A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits". Proc Natl Acad Sci U S A. 95 (22): 13307–12. doi:10.1073/pnas.95.22.13307. PMC 23793Freely accessible. PMID 9789084. 
  4. ^ a b "Entrez Gene: RGS11 regulator of G-protein signalling 11". 

Further reading[edit]