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Regulator of G-protein signaling 12
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS12 ; DKFZp761K1617; DKFZp761K1817
External IDs OMIM602512 MGI1918979 HomoloGene2195 IUPHAR: 2819 ChEMBL: 1293276 GeneCards: RGS12 Gene
RNA expression pattern
PBB GE RGS12 209637 s at tn.png
PBB GE RGS12 205823 at tn.png
PBB GE RGS12 214361 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6002 71729
Ensembl ENSG00000159788 ENSMUSG00000029101
UniProt O14924 Q8CGE9
RefSeq (mRNA) NM_002926 NM_001163512
RefSeq (protein) NP_002917 NP_001156984
Location (UCSC) Chr 4:
3.29 – 3.44 Mb
Chr 5:
34.95 – 35.04 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.[1][2]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.[2]


RGS12 has been shown to interact with GNAI1[3] and GNAI3.[3]


  1. ^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
  2. ^ a b "Entrez Gene: RGS12 regulator of G-protein signalling 12". 
  3. ^ a b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. (United States) 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. 

Further reading[edit]