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Available structures
PDB Ortholog search: PDBe RCSB
Aliases RGS12, regulator of G protein signaling 12
External IDs MGI: 1918979 HomoloGene: 2195 GeneCards: RGS12
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for RGS12
Genomic location for RGS12
Band 4p16.3 Start 3,293,028 bp[1]
End 3,439,913 bp[1]
RNA expression pattern
PBB GE RGS12 214361 s at fs.png

PBB GE RGS12 205823 at fs.png

PBB GE RGS12 209637 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC) Chr 4: 3.29 – 3.44 Mb Chr 4: 34.95 – 35.04 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.[5][6]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.[6]


RGS12 has been shown to interact with GNAI1[7] and GNAI3.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159788 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029101 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (August 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem. 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
  6. ^ a b "Entrez Gene: RGS12 regulator of G-protein signalling 12". 
  7. ^ a b Kimple, R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P (August 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. United States. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333. 

Further reading[edit]