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Protein RGS16 PDB 2ik8.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRGS16, A28-RGS14, A28-RGS14P, RGS-R, regulator of G-protein signaling 16, regulator of G protein signaling 16
External IDsMGI: 108407 HomoloGene: 2196 GeneCards: RGS16
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RGS16
Genomic location for RGS16
Band1q25.3Start182,598,623 bp[1]
End182,604,408 bp[1]
RNA expression pattern
PBB GE RGS16 209325 s at fs.png

PBB GE RGS16 209324 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 182.6 – 182.6 MbChr 1: 153.74 – 153.75 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene.[5][6]


The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.[6]


RGS16 has been shown to interact with GNAQ[7] and GNAI3.[8][9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143333 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026475 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Snow BE, Antonio L, Suggs S, Siderovski DP (Jan 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene. 206 (2): 247–53. doi:10.1016/S0378-1119(97)00593-3. PMID 9469939.
  6. ^ a b "Entrez Gene: RGS16 regulator of G-protein signalling 16".
  7. ^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  8. ^ Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  9. ^ Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. PMID 10072511.

Further reading[edit]