RGS3

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RGS3
Protein RGS3 PDB 2f5y.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RGS3, C2PA, RGP3, regulator of G-protein signaling 3
External IDs MGI: 1354734 HomoloGene: 32440 GeneCards: RGS3
RNA expression pattern
PBB GE RGS3 203823 at fs.png

PBB GE RGS3 220300 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081650
NM_019492
NM_134257
NM_001310706

RefSeq (protein)
Location (UCSC) Chr 9: 113.44 – 113.6 Mb Chr 4: 62.56 – 62.7 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.[3][4][5]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223. 
  4. ^ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339. 
  5. ^ a b "Entrez Gene: RGS3 regulator of G-protein signalling 3". 

Further reading[edit]