RGS5

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RGS5
Protein RGS5 PDB 2crp.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDs MGI: 1098434 HomoloGene: 2682 GeneCards: RGS5
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RGS5
Genomic location for RGS5
Band 1q23.3 Start 163,111,121 bp[1]
End 163,321,791 bp[1]
RNA expression pattern
PBB GE RGS5 209070 s at fs.png

PBB GE RGS5 218353 at fs.png

PBB GE RGS5 209071 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195303
NM_001254748
NM_001254749
NM_003617
NM_025226

NM_009063
NM_001313705

RefSeq (protein)

NP_001182232
NP_001241677
NP_001241678
NP_003608
NP_003608.1

NP_001300634
NP_033089

Location (UCSC) Chr 1: 163.11 – 163.32 Mb Chr 1: 169.66 – 169.7 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[5][6]

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][6]

Interactions[edit]

RGS5 has been shown to interact with GNAO1,[7][8] GNAI2[7][8] and GNAI3.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143248 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026678 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi:10.1007/s100380050071. PMID 9747037. 
  6. ^ a b "Entrez Gene: RGS5 regulator of G-protein signalling 5". 
  7. ^ a b c Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. ISSN 0021-9258. PMID 9079700. 
  8. ^ a b c Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN 0024-3205. PMID 11253162. 

Further reading[edit]