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Regulator of G-protein signaling 6
Protein RGS6 PDB 2es0.png
PDB rendering based on 2es0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RGS6 ; GAP
External IDs OMIM603894 MGI1354730 HomoloGene68385 GeneCards: RGS6 Gene
RNA expression pattern
PBB GE RGS6 214538 x at tn.png
PBB GE RGS6 210270 at tn.png
PBB GE RGS6 211448 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9628 50779
Ensembl ENSG00000182732 ENSMUSG00000021219
UniProt P49758 Q9Z2H2
RefSeq (mRNA) NM_001204416 NM_001282061
RefSeq (protein) NP_001191345 NP_001268990
Location (UCSC) Chr 14:
71.93 – 72.57 Mb
Chr 12:
82.62 – 83.16 Mb
PubMed search [1] [2]

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.[1][2][3]

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM][3]


RGS6 has been shown to interact with STMN2[4] and DMAP1.[2]


  1. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". J Hum Genet 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744. 
  2. ^ a b Liu Z, Fisher RA (March 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". J Biol Chem 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556. 
  3. ^ a b "Entrez Gene: RGS6 regulator of G-protein signalling 6". 
  4. ^ Liu, Zhengyu; Chatterjee Tapan K; Fisher Rory A (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. (United States) 277 (40): 37832–9. doi:10.1074/jbc.M205908200. ISSN 0021-9258. PMID 12140291. 

Further reading[edit]