RGS7

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RGS7
Protein RGS7 PDB 2a72.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RGS7
External IDs MGI: 1346089 HomoloGene: 2193 GeneCards: RGS7
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE RGS7 206290 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282773
NM_001282775
NM_001282778
NM_002924

NM_001199003
NM_011880
NM_001347195

RefSeq (protein)

NP_001269702
NP_001269704
NP_001269707
NP_002915

NP_036010.2
NP_001185932
NP_001334124
NP_036010

Location (UCSC) Chr 1: 240.78 – 241.36 Mb Chr 1: 175.06 – 175.49 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.[4][5]

RGS7 is highly enriched in the brain where it acts as a universal inhibitor of Gi/o-coupled GPCR. RGS7 is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation and acting as intracellular antagonists of GPCR signaling.[6]

Interactions[edit]

RGS7 has been shown to interact with:

References[edit]

  1. ^ "Diseases that are genetically associated with RGS7 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell. 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815. 
  5. ^ "Entrez Gene: RGS7 regulator of G-protein signalling 7". 
  6. ^ Anderson GR, Posokhova E, Martemyanov KA (July 2009). "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1-3): 33–46. doi:10.1007/s12013-009-9052-9. PMC 2827338Freely accessible. PMID 19521673. 
  7. ^ Levay K, Cabrera JL, Satpaev DK, Slepak VZ (Mar 1999). "Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814Freely accessible. PMID 10051672. 
  8. ^ Posner BA, Gilman AG, Harris BA (Oct 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509. 
  9. ^ a b Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA (June 11, 2012). "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. doi:10.1083/jcb.201202123. PMC 3373406Freely accessible. PMID 22689652. 
  10. ^ Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G (May 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888Freely accessible. PMID 10339594. 
  11. ^ Hunt RA, Edris W, Chanda PK, Nieuwenhuijsen B, Young KH (Apr 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861. 

Further reading[edit]