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Rhomboid 5 homolog 1 (Drosophila)
Symbols RHBDF1 ; C16orf8; Dist1; EGFR-RS; gene-89; gene-90; hDist1
External IDs OMIM614403 MGI104328 HomoloGene32085 GeneCards: RHBDF1 Gene
RNA expression pattern
PBB GE RHBDF1 218686 s at tn.png
More reference expression data
Species Human Mouse
Entrez 64285 13650
Ensembl ENSG00000007384 ENSMUSG00000020282
UniProt Q96CC6 Q6PIX5
RefSeq (mRNA) NM_022450 NM_001291818
RefSeq (protein) NP_071895 NP_001278747
Location (UCSC) Chr 16:
0.06 – 0.08 Mb
Chr 11:
32.21 – 32.22 Mb
PubMed search [1] [2]

Inactive rhomboid protein 1 (iRhom1) also known as rhomboid 5 homolog 1 or rhomboid family member 1 (RHBDF1) is a protein that in humans is encoded by the RHBDF1 gene.[1][2][3] The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane serine proteases.[4][5]


  1. ^ Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF (Aug 1993). "Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse". Mamm Genome 4 (6): 314–323. doi:10.1007/BF00357090. PMID 8318735. 
  2. ^ Nakagawa T, Guichard A, Castro CP, Xiao Y, Rizen M, Zhang HZ, Hu D, Bang A, Helms J, Bier E, Derynck R (Jul 2005). "Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands". Dev Dyn 233 (4): 1315–1331. doi:10.1002/dvdy.20450. PMID 15965977. 
  3. ^ "Entrez Gene: RHBDF1 rhomboid 5 homolog 1 (Drosophila)". 
  4. ^ Lemberg MK, Freeman M (November 2007). "Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases". Genome Res. 17 (11): 1634–46. doi:10.1101/gr.6425307. PMC 2045146. PMID 17938163. 
  5. ^ Zettl M, Adrain C, Strisovsky K, Lastun V, Freeman M (April 2011). "Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling". Cell 145 (1): 79–91. doi:10.1016/j.cell.2011.02.047. PMC 3149277. PMID 21439629. 

Further reading[edit]