From Wikipedia, the free encyclopedia
Jump to: navigation, search
Rh family, C glycoprotein
Rhcg 3hd6.png
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RHCG ; C15orf6; PDRC2; RHGK; SLC42A3
External IDs OMIM605381 MGI1888517 HomoloGene32310 GeneCards: RHCG Gene
RNA expression pattern
PBB GE RHCG 219554 at tn.png
More reference expression data
Species Human Mouse
Entrez 51458 56315
Ensembl ENSG00000140519 ENSMUSG00000030549
UniProt Q9UBD6 Q9QXP0
RefSeq (mRNA) NM_016321 NM_019799
RefSeq (protein) NP_057405 NP_062773
Location (UCSC) Chr 15:
89.47 – 89.5 Mb
Chr 7:
79.59 – 79.62 Mb
PubMed search [1] [2]

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[1][2]


RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein[4] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.


  1. ^ "Entrez Gene: RHCG Rh family, C glycoprotein". 
  2. ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913. 
  3. ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature 456 (7220): 339–43. doi:10.1038/nature07518. PMID 19020613. 
  4. ^ PDB: 3hd6​; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. doi:10.1073/pnas.1003587107. PMC 2906887. PMID 20457942. 

Further reading[edit]