From Wikipedia, the free encyclopedia
Jump to: navigation, search
Rhcg 3hd6.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases RHCG, C15orf6, PDRC2, RHGK, SLC42A3, Rh family C glycoprotein
External IDs MGI: 1888517 HomoloGene: 32310 GeneCards: RHCG
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for RHCG
Genomic location for RHCG
Band 15q26.1 Start 89,471,398 bp[1]
End 89,496,613 bp[1]
RNA expression pattern
PBB GE RHCG 219554 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 15: 89.47 – 89.5 Mb Chr 15: 79.59 – 79.62 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[5][6]


RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[7] The structure of the RHCG protein[8] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140519 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030549 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ "Entrez Gene: RHCG Rh family, C glycoprotein". 
  6. ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. PMID 10852913. doi:10.1074/jbc.M003353200. 
  7. ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature. 456 (7220): 339–43. PMID 19020613. doi:10.1038/nature07518. 
  8. ^ PDB: 3hd6​; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. PMC 2906887Freely accessible. PMID 20457942. doi:10.1073/pnas.1003587107. 

Further reading[edit]