RHCG

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RHCG
Rhcg 3hd6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RHCG, C15orf6, PDRC2, RHGK, SLC42A3, Rh family C glycoprotein
External IDs MGI: 1888517 HomoloGene: 32310 GeneCards: 51458
RNA expression pattern
PBB GE RHCG 219554 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016321
NM_001321041

NM_019799

RefSeq (protein)

NP_057405.1

NP_062773.2

Location (UCSC) Chr 15: 89.47 – 89.5 Mb Chr 7: 79.59 – 79.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Rh family, C glycoprotein, also known as RHCG, is a protein that in humans is encoded by the RHCG gene.[1][2]

Function[edit]

RHCG plays a critical role in ammonium handling and pH homeostasis in the kidney.[3] The structure of the RHCG protein[4] indicates that it has a hydrophobic ammonia-conducting channel and shows that it shares a common fold with the ammonia transporters, thus making it an ammonia transporter.

References[edit]

  1. ^ "Entrez Gene: RHCG Rh family, C glycoprotein". 
  2. ^ Liu Z, Chen Y, Mo R, Hui C, Cheng JF, Mohandas N, Huang CH (August 2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913. 
  3. ^ Biver S, Belge H, Bourgeois S, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM (November 2008). "A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility". Nature 456 (7220): 339–43. doi:10.1038/nature07518. PMID 19020613. 
  4. ^ PDB: 3hd6​; Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM (May 2010). "Function of human Rh based on structure of RhCG at 2.1 A". Proc. Natl. Acad. Sci. U.S.A. 107 (21): 9638–43. doi:10.1073/pnas.1003587107. PMC 2906887. PMID 20457942. 

Further reading[edit]