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RIC3 acetylcholine receptor chaperone
Symbols RIC3 ; AYST720; PRO1385
External IDs OMIM610509 MGI2443887 HomoloGene49772 GeneCards: RIC3 Gene
RNA expression pattern
PBB GE RIC3 220282 at tn.png
More reference expression data
Species Human Mouse
Entrez 79608 320360
Ensembl ENSG00000166405 ENSMUSG00000048330
UniProt Q7Z5B4 Q8BPM6
RefSeq (mRNA) NM_001135109 NM_001038624
RefSeq (protein) NP_001128581 NP_001033713
Location (UCSC) Chr 11:
8.13 – 8.19 Mb
Chr 7:
109.03 – 109.08 Mb
PubMed search [1] [2]

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[1] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[2][3] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[4]


  1. ^ Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics 140 (2): 527–35. PMID 7498734. 
  2. ^ Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem 278 (36): 34411–7. doi:10.1074/jbc.M300170200. PMID 12821669. 
  3. ^ "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)". 
  4. ^ Williams ME, Burton B, Urrutia A et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725. 

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