RIC3

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RIC3 acetylcholine receptor chaperone
Identifiers
Symbols RIC3 ; AYST720; PRO1385
External IDs OMIM610509 MGI2443887 HomoloGene49772 GeneCards: RIC3 Gene
RNA expression pattern
PBB GE RIC3 220282 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 79608 320360
Ensembl ENSG00000166405 ENSMUSG00000048330
UniProt Q7Z5B4 Q8BPM6
RefSeq (mRNA) NM_001135109 NM_001038624
RefSeq (protein) NP_001128581 NP_001033713
Location (UCSC) Chr 11:
8.13 – 8.19 Mb
Chr 7:
109.03 – 109.08 Mb
PubMed search [1] [2]

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a chaperone protein that in humans is encoded by the RIC3 gene. The RIC3 gene was first discovered in C. elegans.[1] RIC-3 protein is conserved in most animals and influences the maturation of various ligand gated ion channels including the serotonin 5-HT3 receptor and nicotinic acetylcholine receptors,[2][3] particularly the homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.[4]

References[edit]

  1. ^ Nguyen M, Alfonso A, Johnson CD, Rand JB (Jun 1995). "Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase". Genetics 140 (2): 527–35. PMID 7498734. 
  2. ^ Halevi S, Yassin L, Eshel M, Sala F, Sala S, Criado M, Treinin M (Sep 2003). "Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression". J Biol Chem 278 (36): 34411–7. doi:10.1074/jbc.M300170200. PMID 12821669. 
  3. ^ "Entrez Gene: RIC3 resistance to inhibitors of cholinesterase 3 homolog (C. elegans)". 
  4. ^ Williams ME, Burton B, Urrutia A et al. (2005). "Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells". J. Biol. Chem. 280 (2): 1257–63. doi:10.1074/jbc.M410039200. PMID 15504725. 

Further reading[edit]