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Receptor-interacting serine-threonine kinase 2
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM603455 MGI1891456 HomoloGene37856 ChEMBL: 5014 GeneCards: RIPK2 Gene
EC number,
RNA expression pattern
PBB GE RIPK2 209544 at tn.png
PBB GE RIPK2 209545 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8767 192656
Ensembl ENSG00000104312 ENSMUSG00000041135
UniProt O43353 P58801
RefSeq (mRNA) NM_003821 NM_138952
RefSeq (protein) NP_003812 NP_620402
Location (UCSC) Chr 8:
89.76 – 89.79 Mb
Chr 4:
16.12 – 16.16 Mb
PubMed search [1] [2]

Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene.[1][2][3]

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-κB and inducer of apoptosis in response to various stimuli.[3]


RIPK2 has been shown to interact with BIRC2.[2]{[4]


  1. ^ Inohara N, del Peso L, Koseki T, Chen S, Nunez G (Jun 1998). "RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis". J Biol Chem 273 (20): 12296–300. doi:10.1074/jbc.273.20.12296. PMID 9575181. 
  2. ^ a b Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (Nov 1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr Biol 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938. 
  3. ^ a b "Entrez Gene: RIPK2 receptor-interacting serine-threonine kinase 2". 
  4. ^ McCarthy, J V; Ni J; Dixit V M (Jul 1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. (UNITED STATES) 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. ISSN 0021-9258. PMID 9642260. 

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