RIPK3

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RIPK3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RIPK3, RIP3, receptor interacting serine/threonine kinase 3
External IDs MGI: 2154952 HomoloGene: 31410 GeneCards: RIPK3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006871

NM_001164107
NM_001164108
NM_019955

RefSeq (protein)

NP_006862

NP_064339.2
NP_001157579
NP_001157580
NP_064339

Location (UCSC) Chr 14: 24.34 – 24.34 Mb Chr 14: 55.78 – 55.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.[3][4][5][6]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.[5]

Interactions[edit]

RIPK3 has been shown to interact with RIPK1.[3][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y (Jun 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr Biol. 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. PMID 10339433. 
  4. ^ Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM (Jul 1999). "RIP3, a novel apoptosis-inducing kinase". J Biol Chem. 274 (24): 16871–5. doi:10.1074/jbc.274.24.16871. PMID 10358032. 
  5. ^ a b "Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3". 
  6. ^ a b Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (July 2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150 (2):339-50.doi: 10.1016/j.cell.2012.06.019. PMID 22817896

Further reading[edit]