RIPK5

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DSTYK
Identifiers
Aliases DSTYK, CAKUT1, DustyPK, RIP5, RIPK5, HDCMD38P, dual serine/threonine and tyrosine protein kinase
External IDs MGI: 1925064 HomoloGene: 19711 GeneCards: DSTYK
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE RIPK5 214663 at fs.png

PBB GE RIPK5 211515 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015375
NM_199462

NM_172516

RefSeq (protein)

NP_056190
NP_955749

NP_766104.2
NP_766104

Location (UCSC) Chr 1: 205.14 – 205.21 Mb Chr 1: 132.42 – 132.47 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Dual serine/threonine and tyrosine protein kinase is an enzyme that in humans is encoded by the DSTYK gene.[4][5]

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.[5]

In melanocytic cells RIPK5 gene expression may be regulated by MITF.[6]

References[edit]

  1. ^ "Diseases that are genetically associated with DSTYK view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Zha J, Zhou Q, Xu LG, Chen D, Li L, Zhai Z, Shu HB (Jun 2004). "RIP5 is a RIP-homologous inducer of cell death". Biochem Biophys Res Commun. 319 (2): 298–303. doi:10.1016/j.bbrc.2004.04.194. PMID 15178406. 
  5. ^ a b "Entrez Gene: RIPK5 receptor interacting protein kinase 5". 
  6. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]