TRNA pseudouridine13 synthase

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TRNA pseudouridine13 synthase
Identifiers
EC number 5.4.99.27
CAS number 430429-15-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA pseudouridine13 synthase (EC 5.4.99.27, TruD, YgbO, tRNA PSI13 synthase, RNA:PSI-synthase Pus7p, Pus7p, RNA:pseudouridine-synthase Pus7p, Pus7 protein) is an enzyme with systematic name tRNA-uridine13 uracil mutase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

tRNA uridine13 tRNA pseudouridine13

Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA.

References[edit]

  1. ^ Ericsson, U.B.; Nordlund, P.; Hallberg, B.M. (2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Lett. 565: 59–64. PMID 15135053. doi:10.1016/j.febslet.2004.03.085. 
  2. ^ Chan, C.M.; Huang, R.H. (2009). "Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases". Arch. Biochem. Biophys. 489: 15–19. PMID 19664587. doi:10.1016/j.abb.2009.07.023. 
  3. ^ Kaya, Y.; Ofengand, J. (2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA. 9: 711–721. PMC 1370438Freely accessible. PMID 12756329. doi:10.1261/rna.5230603. 
  4. ^ Behm-Ansmant, I.; Urban, A.; Ma, X.; Yu, Y.T.; Motorin, Y.; Branlant, C. (2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs". RNA. 9: 1371–1382. PMC 1287059Freely accessible. PMID 14561887. doi:10.1261/rna.5520403. 
  5. ^ Urban, A.; Behm-Ansmant, I.; Branlant, C.; Motorin, Y. (2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p". J. Biol. Chem. 284: 5845–5858. PMID 19114708. doi:10.1074/jbc.m807986200. 

External links[edit]