TRNA pseudouridine13 synthase

From Wikipedia, the free encyclopedia
  (Redirected from RNA:PSI-synthase Pus7p)
Jump to: navigation, search
TRNA pseudouridine13 synthase
EC number
CAS number 430429-15-5
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNA pseudouridine13 synthase (EC, TruD, YgbO, tRNA PSI13 synthase, RNA:PSI-synthase Pus7p, Pus7p, RNA:pseudouridine-synthase Pus7p, Pus7 protein) is an enzyme with systematic name tRNA-uridine13 uracil mutase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

tRNA uridine13 tRNA pseudouridine13

Pseudouridine synthase TruD from Escherichia coli specifically acts on uridine13 in tRNA.


  1. ^ Ericsson, U.B.; Nordlund, P.; Hallberg, B.M. (2004). "X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold". FEBS Lett. 565: 59–64. PMID 15135053. doi:10.1016/j.febslet.2004.03.085. 
  2. ^ Chan, C.M.; Huang, R.H. (2009). "Enzymatic characterization and mutational studies of TruD—the fifth family of pseudouridine synthases". Arch. Biochem. Biophys. 489: 15–19. PMID 19664587. doi:10.1016/ 
  3. ^ Kaya, Y.; Ofengand, J. (2003). "A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya". RNA. 9: 711–721. PMC 1370438Freely accessible. PMID 12756329. doi:10.1261/rna.5230603. 
  4. ^ Behm-Ansmant, I.; Urban, A.; Ma, X.; Yu, Y.T.; Motorin, Y.; Branlant, C. (2003). "The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Ψ-synthase also acting on tRNAs". RNA. 9: 1371–1382. PMC 1287059Freely accessible. PMID 14561887. doi:10.1261/rna.5520403. 
  5. ^ Urban, A.; Behm-Ansmant, I.; Branlant, C.; Motorin, Y. (2009). "RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:Ψ-synthase Pus7p". J. Biol. Chem. 284: 5845–5858. PMID 19114708. doi:10.1074/jbc.m807986200. 

External links[edit]