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Ribonuclease, RNase A family, 1 (pancreatic)
Protein RNASE1 PDB 1dza.png
PDB rendering based on 1dza.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols RNASE1 ; RAC1; RIB1; RNS1
External IDs OMIM180440 MGI97919 HomoloGene7919 ChEMBL: 5425 GeneCards: RNASE1 Gene
EC number
RNA expression pattern
PBB GE RNASE1 201785 at tn.png
More reference expression data
Species Human Mouse
Entrez 6035 19752
Ensembl ENSG00000129538 ENSMUSG00000035896
UniProt P07998 P00683
RefSeq (mRNA) NM_002933 NM_011271
RefSeq (protein) NP_002924 NP_035401
Location (UCSC) Chr 14:
20.8 – 20.8 Mb
Chr 14:
51.15 – 51.15 Mb
PubMed search [1] [2]

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]


This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]


  1. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia 21 (9): 691–4. PMID 8588814. 
  2. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)". 

Further reading[edit]