RNASE1

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RNASE1
Protein RNASE1 PDB 1dza.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
External IDs MGI: 97919 HomoloGene: 7919 GeneCards: 6035
RNA expression pattern
PBB GE RNASE1 201785 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198235
NM_002933
NM_198232
NM_198234

NM_011271

RefSeq (protein)

NP_002924.1
NP_937875.1
NP_937877.1
NP_937878.1

n/a

Location (UCSC) Chr 14: 20.8 – 20.8 Mb Chr 14: 51.15 – 51.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]

Function[edit]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]

References[edit]

  1. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia 21 (9): 691–4. PMID 8588814. 
  2. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)". 

Further reading[edit]