RNASE1

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RNASE1
Protein RNASE1 PDB 1dza.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic
External IDsOMIM: 180440 MGI: 97919 HomoloGene: 7919 GeneCards: RNASE1
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for RNASE1
Genomic location for RNASE1
Band14q11.2Start20,801,228 bp[1]
End20,802,855 bp[1]
RNA expression pattern
PBB GE RNASE1 201785 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198235
NM_002933
NM_198232
NM_198234

NM_011271

RefSeq (protein)

NP_002924
NP_937875
NP_937877
NP_937878

NP_035401

Location (UCSC)Chr 14: 20.8 – 20.8 MbChr 14: 51.14 – 51.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[5][6]

Function[edit]

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129538 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035896 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia. 21 (9): 691–4. PMID 8588814.
  6. ^ a b "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)".

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribonuclease pancreatic