RNF11

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RNF11
Identifiers
Aliases RNF11, SID1669, CGI-123, ring finger protein 11
External IDs MGI: 1352759 HomoloGene: 32195 GeneCards: RNF11
RNA expression pattern
PBB GE RNF11 208924 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014372

NM_013876

RefSeq (protein)

NP_055187

NP_038904.1
NP_038904

Location (UCSC) Chr 1: 51.24 – 51.27 Mb Chr 4: 109.45 – 109.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[3][4][5]

Function[edit]

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[5]

See also[edit]

Interactions[edit]

RNF11 has been shown to interact with RIPK1[6] and STAMBP.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (March 2000). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2-3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.  Check date values in: |year= / |date= mismatch (help)
  4. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093. 
  5. ^ a b "Entrez Gene: RNF11 ring finger protein 11". 
  6. ^ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574Freely accessible. PMID 19131965. 
  7. ^ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. 

Further reading[edit]

External links[edit]