RNF111

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RNF111
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNF111, ARK, ring finger protein 111, hRNF111
External IDs MGI: 1934919 HomoloGene: 9741 GeneCards: RNF111
Gene location (Human)
Chromosome 15 (human)
Chr. Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for RNF111
Genomic location for RNF111
Band 15q22.1-q22.2 Start 58,865,175 bp[1]
End 59,097,419 bp[1]
RNA expression pattern
PBB GE RNF111 218761 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270528
NM_001270529
NM_001270530
NM_017610
NM_001330331

NM_033604
NM_001357494

RefSeq (protein)

NP_001257457
NP_001257458
NP_001257459
NP_001317260
NP_060080

NP_291082
NP_001344423

Location (UCSC) Chr 15: 58.87 – 59.1 Mb Chr 9: 70.43 – 70.5 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[5][6]

Function[edit]

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[6]

Interactions[edit]

RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[7] and Mothers against decapentaplegic homolog 3.[7][8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157450 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032217 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature. 410 (6830): 825–30. doi:10.1038/35071095. PMID 11298452. 
  6. ^ a b "Entrez Gene: RNF111 ring finger protein 111". 
  7. ^ a b Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMC 291827Freely accessible. PMID 14657019. 
  8. ^ Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone. 44 (1): 53–60. doi:10.1016/j.bone.2008.09.013. PMID 18950738. 

Further reading[edit]