RNF128

From Wikipedia, the free encyclopedia
Jump to: navigation, search
RNF128
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNF128, GRAIL, ring finger protein 128, E3 ubiquitin protein ligase
External IDs MGI: 1914139 HomoloGene: 11337 GeneCards: RNF128
RNA expression pattern
PBB GE RNF128 219263 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_194463
NM_024539

NM_001254761
NM_023270

RefSeq (protein)

NP_078815
NP_919445

NP_001241690.1
NP_075759.3
NP_001241690
NP_075759

Location (UCSC) Chr X: 106.69 – 106.8 Mb Chr X: 139.56 – 139.67 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF128 is an enzyme that in humans is encoded by the RNF128 gene.[3]

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions[edit]

RNF128 has been shown to interact with CD154[4] and OTUB1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: RNF128 ring finger protein 128". 
  4. ^ Lineberry, Neil B; Su Leon L; Lin Jack T; Coffey Greg P; Seroogy Christine M; Fathman C Garrison (Aug 2008). "Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy". J. Immunol. United States. 181 (3): 1622–6. doi:10.4049/jimmunol.181.3.1622. PMC 2853377Freely accessible. PMID 18641297. 
  5. ^ Soares, Luis; Seroogy Christine; Skrenta Heidi; Anandasabapathy Niroshana; Lovelace Patricia; Chung Chan D; Engleman Edgar; Fathman C Garrison (Jan 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. United States. 5 (1): 45–54. doi:10.1038/ni1017. ISSN 1529-2908. PMID 14661020. 

Further reading[edit]