RNF25

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RNF25
Protein RNF25 PDB 2day.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNF25, AO7, ring finger protein 25
External IDs MGI: 1890215 HomoloGene: 11193 GeneCards: RNF25
RNA expression pattern
PBB GE RNF25 218861 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022453

NM_021313
NM_001305230

RefSeq (protein)

NP_071898

NP_001292159.1
NP_067288.2
NP_001292159
NP_067288

Location (UCSC) Chr 2: 218.66 – 218.67 Mb Chr 1: 74.59 – 74.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[3][4]

Function[edit]

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[4]

Interactions[edit]

RNF25 has been shown to interact with RELA.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188. 
  4. ^ a b "Entrez Gene: RNF25 ring finger protein 25". 

Further reading[edit]

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039Freely accessible. PMID 10500182. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.