RNF8

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RNF8
Protein RNF8 PDB 2csw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RNF8, hring finger protein 8
External IDs MGI: 1929069 HomoloGene: 2944 GeneCards: 9025
RNA expression pattern
PBB GE RNF8 203160 s at tn.png

PBB GE RNF8 203161 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003958
NM_183078

NM_021419

RefSeq (protein)

NP_003949.1
NP_898901.1

NP_067394.1

Location (UCSC) Chr 6: 37.35 – 37.39 Mb Chr 17: 29.61 – 29.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.[1][2][3]

Function[edit]

The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as a ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions[edit]

RNF8 has been shown to interact with Retinoid X receptor alpha.[4]

See also[edit]

References[edit]

  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Ohhira M, Muramatsu M, Hori T, Saito T (Jan 1999). "Isolation, tissue expression, and chromosomal assignment of a novel human gene which encodes a protein with RING finger motif". Journal of Human Genetics 43 (4): 272–4. doi:10.1007/s100380050088. PMID 9852682. 
  3. ^ a b "Entrez Gene: RNF8 ring finger protein 8". 
  4. ^ Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y (Apr 2004). "The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity". The Journal of Biological Chemistry 279 (18): 18926–34. doi:10.1074/jbc.M309148200. PMID 14981089. 

Further reading[edit]

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (May 2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". European Journal of Biochemistry / FEBS 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894. 
  • Takano Y, Adachi S, Okuno M, Muto Y, Yoshioka T, Matsushima-Nishiwaki R, Tsurumi H, Ito K, Friedman SL, Moriwaki H, Kojima S, Okano Y (Apr 2004). "The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity". The Journal of Biological Chemistry 279 (18): 18926–34. doi:10.1074/jbc.M309148200. PMID 14981089. 
  • Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D (Dec 2007). "Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase". Science 318 (5856): 1637–40. doi:10.1126/science.1150034. PMC 2430610. PMID 18006705. 

External links[edit]